Identification and characterization of novel positive allosteric modulators of the Dopamine D1 Receptor

Identifying therapeutic candidates for Schizophrenia through HTS

This Poster summarizes a study from the London Centre for Therapeutics Discovery investigating allosteric modulators of the Dopamine D1 receptor, in order to identify potential therapeutic candidates for the treatment of Schizophrenia.


  • Methodology followed by the authors
  • Key results of the study (HTS performance and hit rates)
  • Conclusion suggesting the identification of a novel allosteric modulator


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4 GPCR challenges, 1 solution

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Studying GPCRs? This poster describes the use of HTRF® as a single homogeneous signaling technology, for compound characterization and receptor studies. Take a look!

Ultimate guides to master Gs and Gi GPCR assays

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New to cAMP assays? Or simply wish to review the basics? These complete guides feature tips on performing and optimizing cAMP assays for more significant results. Get them now!