High-Throughput Screening of GPCRs for Drug Discovery Applications

Watch HTS of GPCRs for Drug Discovery webinar

What is covered in this webinar:

  • Case studies highlighting screening and assay development of small-molecule antagonists for GPCRs
  • High-throughput-screening for Gq-coupled receptors using fluorescence-based detection of second messengers
  • High-throughput-screening hit selection and compound profiling for GPCRs



Edward Ainscow

Dr. Edward Ainscow 
Director, Genomics Institute of the Novartis Research Foundation.

Sylvie Jezequel-Sur

Sylvie Jezequel-Sur
MS, Associate Principal Scientist, Merck & Co.

R. Jason Kirby

R. Jason Kirby
MS, Senior Associate Scientist, Sanford Burnham Prebys Medical Discovery Institute.


GPCRs constitute the largest class of protein targets for pharmacological manipulation. However, technical challenges persist in the rapid screening of GPCR agonists and antagonists. A panel of experts will discuss advances in high-throughput screening for GPCR drug discovery.