Lit Review

Fibrosis study investigating the role of the extracellular matrix in fibrosis disorder

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Dive deeper into fibrosis research

In fibrotic disorders, the normal regulation of the extracellular matrix (ECM) is compromised, which leads to excess of ECM or lack of MMPs. This can further lead to a disorganized accumulation of ECM which can ultimately result in organ rigidity and fibrosis. For this reason, the ECM constitutive proteins, MMPs and fibroblasts activating and regulatory mediators such as TGF-β1 and PGE2 are hot spots of therapeutic research for fibrosis.

With this review, you will:

  • Better understand how COX enzymes regulate PGE2 levels in TLR stimulated fibroblasts
  • Learn how an AlphaLISA protein-protein interaction assay can be used as a screening platform for TG2-Fibronectin inhibitor identification
  • Discover how CKD might impact the malignant myocardial fibrosis factor combination

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