Discover a new era of automated T-SPOT™.TB testing.
The TB test you want. The automation you need.
See what's arrived
T-SPOT.TB enables accurate TB testing1 and when paired with our automation solutions you get efficient laboratory workflows without compromising on clinical performance.2
This powerful combination not only simplifies T-SPOT.TB testing but also provides confidence in the result.
- ✓ Efficient workflow, more time for you.
- ✓ Easy to use, easy to get right.
- ✓ Access high-quality testing, be confident in the result.
Less than 10 mins hands-on time once the Auto-Pure 2400 workflow has commenced*
54-hour sample stability2
Only one primary tube needed*
Accurate TB testing with the T-SPOT technology.
The T-SPOT.TB test is an ELISPOT-based interferon-gamma release assay (IGRA) and has crucial steps that have recently been acknowledged for their benefits by the World Health Organization5, these include washing, isolating, and counting the PBMCs before the test is performed. The test also targets functional cells to obtain accurate and reliable results.
See why cells are so important.
The right cells
PBMCs are isolated from whole blood. This step washes cells, removing contaminants which could interfere with the cellular immune response and impact the performance of the assay.3,4
Key benefit: Effective test in patients receiving treatment
Enough of the right cells
Counting cells ensures the same number of cells are used for each test facilitating correction for variations in patient cell counts.5
Standardizing cell numbers helps prevent problems like:
- Too many or too few cells
- Low cell numbers, frequent with autoimmune diseases such as chronic inflammatory bowel diseases or autoimmune hepatitis6
Key benefit: A standard number of cells per test promotes reproducibility
Functioning cells1
Single cell resolution where all spots detect and visualize the response from live cells in the test to determine a TB specific T cell response.
Visualizing cells facilitates:
- Single cell resolution: all spots produced are a footprint of where the IFN-gamma was released
Key benefit: Detect a TB-specific cell mediated response.
High sensitivity and specificity meaning few inaccurate results1
Low indeterminate results, few repeat tests7
Maintains performance in the immunosuppressed4,8
* Mid run user intervention with Auto-Pure 2400 workflow with Cellaca MX
* In immunosuppressed individuals two tubes may be requested
- Oxford Immunotec. T-SPOT.TB Package Insert PI-TB-IVD-UK-v5. Abingdon, UK. November 2023
- T-Cell Select Package Insert PI-TS-IVD-UK-V8 Abingdon, UK. November 2023
- Bèlard, et al. Prednisolone treatment affects the performance of the QuantiFERON gold in-tube test and the tuberculin skin test in patients with autoimmune disorders screened for latent tuberculosis infection. Inflammatory Bowel Diseases, Volume 17, Issue 11, 1 November 2011, Pages 2340–2349.
- Wong SH, Gao Q, Tsoi KK, Wu WK, Tam LS, Lee N, Chan FK, Wu JC, Sung JJ, Ng SC. Effect of immunosuppressive therapy on interferon γ release assay for latent tuberculosis screening in patients with autoimmune diseases: a systematic review and meta-analysis. Thorax. 2016 Jan
- World Health Organization. WHO operational handbook on tuberculosis. October 1, 2022 (https://www.who.int/ publications/i/item/9789240058347)
- Koetz K at al. T cell homeostasis in patients with rheumatoid arthritis. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9203-8. doi: 10.1073/pnas.97.16.9203. PMID: 10922071; PMCID: PMC16846
- Rego K, et al. Utility of the T-SPOT®.TB test’s borderline category to increase test resolution for results around the cut-off point. Tuberculosis. 2018;108:178-185.doi:10.1016/j.tube.2017.12.005.
- Clark SA, Martin SL, Pozniak A, et al. Tuberculosis antigen-specific immune responses can be detected using enzyme-linked immunospot technology in human immunodeficiency virus (HIV)-1 patients with advanced disease. Clin Exp Immunol. 2007;150(2):238-244.
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LPG-MPN906-01
